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Drug resistance is an increasing problem for the treatment of tuberculosis. The prevalence of clinical isolates with pre-existing resistance needs to be considered in any drug discovery program. Non-specific mechanisms of resistance such as increased efflux or decreased permeability need to be considered both in developing individual drug candidates and when designing novel regimens. https://www.lightemupsequences.com/quick-find-Our-Seasons-The-World-in-Winter-Spring-Summer-and-Autumn-best-save/

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