Background: in this study. we examined the risk factors and the effects of substance abuse on the incidence of ischemic heart disease in patients less than 40 years old in Shahid Rajaei Hospital in Karaj from 2019-2020. Methods: This case-control study was done on 70 patients in the cases and 70 cases in the control groups. All demographic data. https://intcariuma.shop/product-category/shoe-care/